Vapes may seem harmless but can actually expose the body to the same level of nicotine as multiple packs of cigarettes, increasing the risk of dependence without people realizing it. Free resources: How Many Puffs of a Vape is Equivalent to a Cigarette? selbyvapes Vaping vs Cigarettes Health Impacts Compared Comparison of Nicotine Levels Between Cigarettes and Vapes Ecigator How Many Puffs Of A 20mg Vape Is Equal To A Cigarette? (High Equivalency) A single vape cartridge can have the nicotine equivalent of 600 cigarettes.